Figure 2
From: Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
Ferric ion-containing transferrin boosted temperature elevation in tumor-bearing mice in the 13.56 MHz radiofrequency hyperthermia in vivo. Tumor-bearing mice were given i.v. injection with either apotransferrin or transferrin and the temperature of tumor tissues was recorded before and after 13.56 MHz radiofrequency hyperthermia for temperature change (ΔT) calculation. The temperature elevation in tumor tissue was dramatically boosted by local hyperthermia using a 13.56 MHz radiofrequency hyperthermia with transferrin but not with apotransferrin. The values represent the mean ± standard deviation (n = 6). A paired Student’s t-test was used for the statistical analysis; ***p < 0.001.
