Figure 3
From: Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
The cancer tissues became more reactive to 13.56 MHz radiofrequency hyperthermia as i.v. injections of transferrin were repeated. (a) The repeated i.v. injections of transferrin to tumor-bearing mice boosted temperature elevation in a local 13.56 MHz radiofrequency hyperthermia as ferric ion accumulated (see Supplementary Fig. 2). (b) The representative images of (a). (c) The repeated i.v. injection of transferrin boosted temperature elevation in a whole-body 13.56 MHz radiofrequency hyperthermia as ferric ion accumulation increased. (d) The representative images of (c). The temperature was measured before and after 13.56 MHz radiofrequency hyperthermia for temperature change (ΔT) calculation. The values represent the mean ± standard deviation (n = 6). A paired Student’s t-test was used for the statistical analysis; ***p < 0.001.
