Figure 4
From: Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
The selective temperature elevations of cancer tissue by a local 13.56 MHz radiofrequency hyperthermia was positively correlated with ferric ion accumulation. Accumulation of ferric ion in cancer cells was achieved by repeated i.v. injection of transferrin as described in Supplementary Fig. 2. The temperature of tumor tissues or normal subcutaneous tissues was measured before and after local hyperthermia for temperature change (ΔT) calculation. (a) The comparative analysis showed that accumulation of ferric ion by repeated i.v. injections of transferrin elevated temperature higher in cancer tissue than in normal subcutaneous tissues in a local hyperthermia. (b) Representative images of transferrin injection group were shown along with apotransferrin injection group. The values represent the mean ± standard deviation (n = 6). A paired Student’s t-test was used for the statistical analysis; ***p < 0.001.
