Figure 5
From: Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
The selective temperature elevation of cancer tissue by a whole-body 13.56 MHz radiofrequency hyperthermia was positively correlated with ferric ion accumulation by repeated injections of transferrin. Accumulation of ferric ion in cancer cells was achieved by repeated i.v. injections of transferrin as described in Supplementary Fig. 2. The temperatures of tumor tissues in either apotransferrin or transferrin injection groups were measured before and after whole-body hyperthermia for temperature changes and relative ratio calculation. (a) The comparative analysis showed that ferric ion accumulation achieved by repeated i.v. injections of transferrin elevated temperature higher in cancer tissue compared to injections of apotransferrin in a whole-body hyperthermia. (b) Representative images of a. The values represent the mean ± standard deviation (n = 6). A paired Student’s t-test was used for the statistical analysis; ***p < 0.001.
