Figure 1 | Scientific Reports

Figure 1

From: Complement regulatory protein CD46 induces autophagy against oxidative stress-mediated apoptosis in normal and asthmatic airway epithelium

Figure 1

Increased apoptosis and decreased CD46 in the nasal mucosa of the asthmatic patients. (A) CD46 expression (red arrow) was increased in the asthmatic patients (n = 10) compared with the healthy controls (n = 10) as shown by immunohistochemical staining. Epithelial cell shedding and a decreased expression of CD46 (red arrow) were noted in the fragile epithelium of the asthmatic patients (n = 10). Representative confocal microscopic analysis between intact nasal epithelium (B) and fragile epithelium (C) from the asthmatic patients. Primary nasal epithelium biopsy stained with TUNEL (FITC), CD46 (PE), and 4′,6-diamidino-2-phenylindole (DAPI) (nuclear stain). The yellow arrows indicate TUNEL-positive cells. Decreased CD46 expression and increased TUNEL staining in the fragile upper airway epithelial cells are shown. Scale bar, 20 um. (D,E) Statistical data of 10 paired experiments between intact and fragile epithelium from asthmatic patients for the number of CD46 and TUNEL-positive cells (% epithelial cells stained) per high-power field. The Kruskal-Wallis test was used. *p < 0.05.

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