Figure 1
From: The Ras-related gene ERAS is involved in human and murine breast cancer
Eras expression in mammary gland tumors with activating transposon insertions in Eras locus. (a) Gene structure of the murine Eras gene showing both the localization and orientation (arrowheads) of the transposon insertions into the first intron of Eras. (b–d) Hematoxylin and eosin staining of murine mammary gland tumors with transposon insertion in the Eras gene. Image b corresponds to alveolar-papillary carcinoma, image c is an adenosquamous carcinoma, and image d is a tubular-papillary carcinoma with an important myoepithelial cell component. (e–g) Immunohistochemistry showing ERAS expression (antibody D5G5J) in the tumors shown in images (b–d) respectively. (h,i) Representative examples of lack of ERAS staining in tumors without insertion in Eras. Bar, 50 μm. Tumor identifications (T1, T2 and T3) are indicated in the lower left corner.
