Figure 8
From: The Ras-related gene ERAS is involved in human and murine breast cancer
ERAS is expressed in human breast cancer. (a) Gene-expression levels of ERAS measured by RT-qPCR in a collection of breast tumors (n = 32). Expression values were normalized using GUSB and TBP genes. (b,c) Immunohistochemical staining of the ERAS-expressing (b) and a non-expressing (c) breast tumors using the ERAS D5G5J antibody. Bar, 100 μm. Tumor identifications (T6 and T20) are indicated in the lower left corner and correspond with numbers in A. (d) Immunohistochemical staining of ERAS in the IDC breast carcinoma samples. Examples from two different slides (upper and lower row) are shown. For each row, left and center images are positive for ERAS staining and right image is negative. Bar, 100 μm. (e) Statistical analysis showing correlation (Chi-square test) between ERAS staining, tumor phenotype and distant metastasis. Only samples with tumor phenotype and clinical parameters were included in the analysis. Significance is shown below.
