Figure 1 | Scientific Reports

Figure 1

From: FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway

Figure 1

Metabolic differences between oxidative and glycolytic subpopulations of TNBC MDA-MB-231 cells. Energy contribution of mitochondrial respiration and intracellular ATP levels of oxidative (a,b) and glycolytic (c,d) subpopulations of TNBC MDA-MB-231 cells. Contribution of fatty acid oxidation (e) and glutaminolysis (f) to mitochondrial respiration. Inhibition of mitochondrial respiration by GDH inhibitor EGCG (100 µM) and reverse by cell permeable metabolite dimethyl-α-ketoglutarate (1 mM, dα-KG) in glycolytic (g) and oxidative (h) subpopulations. AOA: aminooxyacetic acid; EGCG: epigallocatechin-monogallate; IA: iodoacetate; Olig.: oligomycin. Data are expressed as means ± SEM of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0,001 vs Control. n.s.: not significant.

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