Figure 6 | Scientific Reports

Figure 6

From: FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway

Figure 6

R58P1a inhibits the fibronectin-dependent adhesion and migration by Sirt1/AMPK/β1-integrin axis in TNBC MDA-MB-231 cells. (a) Effect of FR58P1a on fibronectin-stimulated adhesion, (b) polylysine-stimulated adhesion and (c) fibronectin-stimulated actin network of MDA-MB-231 cells. (d) Effect of FR58P1a on fibronectin-stimulated migration of MDA-MB-231, (e) BT549 and (f) MCF10A. (g,h) Effect of AMPK and Sirt1 inhibition on anti-migratory effect of FR58P1a. (i) β1-integrin levels in surface of MDA-MB-231 exposed to FR58P1a and AMPK inhibition with Compound C. Data shown are the mean ± SEM of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, vs. Control (DMSO). n.s. not significant.

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