Table 3 Univariate and multivariate analyses of recurrence-free survival (RFS) in the 52 pNEN patients included in this study.

From: Profiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification

RFS in pNENs

univariate analysis

multivariate analysis

variables

HR (95% CI)

p value

HR (95% CI)

p value

Age (60<)

1.458 (0.525–4.051)

0.467

  

Sex (male)

1.257 (0.455–3.472)

0.658

  

Lymph node metastasis

3.458 (1.223–9.776)

0.013

1.770 (0.518–6.061)

0.363

WHO Grade (G1, 2/G3, NEC)

6.993 (2.160–22.727)

0.001

2.179 (0.580–8.197)

0.249

ENETS Stage (I, IIA/IIB-IV)

10.821 (2.430–48.181)

<0.001

9.087 (1.374–60.085)

0.022

CD3+/PD-1 high

5.952 (1.669–21.277)

0.002

1.618 (0.333–7.874)

0.551

CD204+/PD-L1 high

4.884 (1.511–15.784)

0.004

1.751 (0.428–7.156)

0.436

  1. The univariate analysis for age, sex, lymph node metastasis, WHO grade, ENETS stage, and for the immune profiles was performed using the log-rank test. The multivariate analysis was performed using the Cox proportional hazards model.
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