Table 1 Prevalence of H5N1 polymerase mutations in human and avian viruses identified in the database search in this study.
Segment (no. of strains with mutation) | Host of virus with mutation | Mutation | % of strains with mutation (no. of strains)a | |
|---|---|---|---|---|
Human viruses | Bird viruses | |||
PB2 (9) | Only in human viruses | H134R | 12.5 (3) | 0 (0) |
K190R | 8.3 (2) | 0 (0) | ||
M315I | 8.3 (2) | 0 (0) | ||
D701N | 8.3 (2) | 0 (0) | ||
More prevalent in human viruses than in avian viruses | T81A | 12.5 (3) | 1.5 (3) | |
V344M | 16.7 (4) | 3.0 (6) | ||
L618M | 16.7 (4) | 0.5 (1) | ||
Y658H | 12.5 (3) | 2.0 (4) | ||
G685R | 8.3 (2) | 0.5 (1) | ||
PB1 (8) | Only in human viruses | T156V | 8.3 (2) | 0 (0) |
More prevalent in human viruses than in avian viruses | T21S | 8.3 (2) | 0.5 (1) | |
M111I | 12.5 (3) | 0.5 (1) | ||
N314S | 8.3 (2) | 2.0 (4) | ||
N328K | 8.3 (2) | 0.5 (1) | ||
D398E | 8.3 (2) | 0.5 (1) | ||
M744T | 8.3 (2) | 0.5 (1) | ||
K745R | 8.3 (2) | 0.5 (1) | ||
PA (14) | Only in human viruses | M86V | 8.3 (2) | 0 (0) |
F562Y | 8.3 (2) | 0 (0) | ||
More prevalent in human viruses than in avian viruses | S65P | 8.3 (2) | 2.0 (4) | |
T85A | 8.3 (2) | 0.5 (1) | ||
N115S | 8.3 (2) | 0.5 (1) | ||
N222S | 8.3 (2) | 0.5 (1) | ||
A224P | 8.3 (2) | 2.0 (4) | ||
L226F | 8.3 (2) | 0.5 (1) | ||
Y305F | 8.3 (2) | 0.5 (1) | ||
A343T | 16.7 (4) | 0.5 (1) | ||
D394G | 12.5 (3) | 0.5 (1) | ||
E610D | 8.3 (2) | 2.0 (4) | ||
E613V | 16.7 (4) | 0.5 (1) | ||
A689S | 8.3 (2) | 0.5 (1) | ||
NP (2) | More prevalent in human viruses than in avian viruses | T430A | 12.5 (3) | 2.5 (5) |
L466F | 8.3 (2) | 1.5 (3) | ||
