Table 1 List of the 61-significant adjusted P value (Benjamini-Hochberg) corresponding to 18 genes according to the hibernation state (Kruskal-Wallis, adjusted P-values ≤ 0,05) in a tissue-by-tissue analysis.

Organs	Genes	Adjusted P values	Organs	Genes	Adjusted P values
Liver	MT2	0.006	Heart	Tubulin	0.019
Liver	ObR	0.006	Pituitary gland	Dio2	0.025
Liver	Tubulin	0.006	Pituitary gland	Per2	0.025
BAT	Dio2	0.008	Pituitary gland	QR2	0.025
BAT	Per2	0.008	Retina	Bmal1	0.028
Retina	FGF21	0.008	Retina	MT2	0.028
Retina	Per2	0.009	Retina	Per1	0.028
Retina	PPARα	0.009	Retina	QR2	0.028
Hypothalamus	PGC1α	0.01	Retina	Tubulin	0.028
Hypothalamus	PPARα	0.01	Hypothalamus	Per1	0.031
Hypothalamus	Tubulin	0.01	Pituitary gland	Bmal1	0.032
Hypothalamus	Actin	0.011	Pituitary gland	Tubulin	0.032
Hypothalamus	G6PD	0.011	Adrenal glands	Per1	0.036
Hypothalamus	Per2	0.011	Cortex	Per1	0.037
Hypothalamus	Bmal1	0.011	BAT	Per1	0.038
Hypothalamus	RBM3	0.011	Hypothalamus	TXNIP	0.038
Hypothalamus	Rev-Erbα	0.011	Heart	Rev-Erbα	0.039
Hypothalamus	MT2	0.012	Pituitary gland	Rev-Erbα	0.041
BAT	PPARα	0.013	Pituitary gland	Clock	0.041
Adrenal glands	FGF21	0.013	Pituitary gland	FGF21	0.041
Adrenal glands	Per2	0.013	Pituitary gland	TXNIP	0.041
Cortex	Per2	0.014	Liver	Per2	0.041
BAT	Dio3	0.014	Heart	Actin	0.042
Hypothalamus	Clock	0.015	Heart	Dio2	0.042
Hypothalamus	QR2	0.015	Heart	TXNIP	0.042
Hypothalamus	SIRT1	0.015	Hypothalamus	FGF21	0.042
BAT	MT2	0.016	BAT	SIRT1	0.045
Liver	Per1	0.018	Liver	FGF21	0.048
Heart	Per1	0.019	Cortex	Dio2	0.049
Heart	Per2	0.020	Cortex	Dio2	0.049

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