Figure 6
From: Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd
Proposed mechanism for TSAd modulation of T cell polarity upon TCR stimulation. Upon repeated TCR stimulation, TSAd is expressed and modulates the activity of Lck and Itk. Presence of TSAd affects recruitment of Lck and SLP-76 to Nck and promote downstream re-organization of the cytoskeleton and MTOC towards the IS, possibly mediated by activation of Cdc42.
