Table 2 Risk of major cardiovascular events stratified by blood pressure control levels.

From: Blood Pressure Control and Cardiovascular Outcomes: Real-world Implications of the 2017 ACC/AHA Hypertension Guideline

 

10-year event rates (%)

Unadjusted analysis

Multivariable adjustment

Propensity score matching analysis

Below 2017 ACC/AHA target

Below JNC8 but above 2017 ACC/AHA target

Above JNC 8 target

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

2017 ACC/AHA goal vs. JNC8 goal

Composite cardiovascular events

5.47

7.06

—

0.77 (0.75‒0.80)

<0.001

0.79 (0.76‒0.82)

<0.001

0.91 (0.86‒0.97)

0.002

Death from any cause

4.66

5.48

—

0.85 (0.82‒0.88)

<0.001

0.78 (0.74‒0.81)

<0.001

0.82 (0.76‒0.88)

<0.001

Cardiac death

0.88

1.15

—

0.77 (0.71‒0.83)

<0.001

0.71 (0.64‒0.78)

<0.001

0.77 (0.66‒0.89)

<0.001

Myocardial infarction

1.16

1.44

—

0.80 (0.75‒0.86)

<0.001

0.83 (0.77‒0.91)

<0.001

0.94 (0.83‒1.06)

0.297

Stroke

2.63

3.68

—

0.72 (0.68‒0.75)

<0.001

0.74 (0.71‒0.79)

<0.001

0.89 (0.82‒0.96)

0.004

Heart failure

2.12

2.53

—

0.84 (0.79‒0.88)

<0.001

0.82 (0.77‒0.88)

<0.001

0.94 (0.86‒1.03)

0.173

2017 ACC/AHA goal vs. poorly controlled

Composite cardiovascular events

5.47

—

10.84

0.50 (0.49‒0.52)

<0.001

0.55 (0.53‒0.58)

<0.001

0.52 (0.50‒0.54)

<0.001

Death from any cause

4.66

—

7.69

0.60 (0.58‒0.62)

<0.001

0.56 (0.53‒0.58)

<0.001

0.55 (0.52‒0.57)

<0.001

Cardiac death

0.88

—

1.94

0.45 (0.42‒0.49)

<0.001

0.44 (0.40‒0.49)

<0.001

0.43 (0.38‒0.48)

<0.001

Myocardial infarction

1.16

—

2.16

0.54 (0.50‒0.57)

<0.001

0.61 (0.56‒0.66)

<0.001

0.57 (0.52‒0.62)

<0.001

Stroke

2.63

—

5.90

0.44 (0.43‒0.46)

<0.001

0.53 (0.50‒0.56)

<0.001

0.49 (0.46‒0.52)

<0.001

Heart failure

2.12

—

3.66

0.58 (0.55‒0.61)

<0.001

0.59 (0.55‒0.63)

<0.001

0.56 (0.52‒0.60)

<0.001

  1. 2017 ACC/AHA: 2017 American College of Cardiology/American Heart Association Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults; JNC8: Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report from the Panel Members Appointed to the Eighth Joint National Committee; HR: hazard ratio; CI: confidence intervals.
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