Table 1 Demographic, clinical, and laboratory characteristics at renal biopsy.

From: A comparison of the effectiveness of cyclophosphamide, leflunomide, corticosteroids, or conservative management alone in patients with IgA nephropathy: a retrospective observational study

 

P + CTX (n = 85)

P + LEF (n = 73)

P (n = 80)

ACEI/ARB (n = 73)

P value

Age - yr.

37.2 ± 9.7

36.3 ± 12.2

36.3 ± 11.6

35.9 ± 10.7

0.897

Female sex - no. (%)

54(63.5%)

45(61.6%)

50(62.5%)

43(58.9%)

0.944

Duration of disease -mo.

4(3–7)

4(3–6)

4(2–6)

3(2–4)

0.002

MAP (mmHg)

95.4 ± 12.5

95.5 ± 13.7

98.9 ± 15.5

97.4 ± 14.9

0.361

Hypertension (%)

29(34.1%)

21(28.8%)

22(27.5%)

15(20.5%)

0.305

Gross hematuria (%)

24(28.6%)

16(21.9%)

19(22.5%)

22(30.1%)

0.555

eGFR(ml/min/1.73 m2)abce

64.7 ± 35.3

81.1 ± 30.4

89.3 ± 30.4

91.6 ± 29.2

p < 0.001

Cr (umol/L)abc

123.1 ± 49.3

99.0 ± 43.1

99.9 ± 43.6

86.8 ± 33.8

p < 0.001

UA (mmol/L)

384.8 ± 113.7

355.0 ± 116.8

372.3 ± 109.2

361.8 ± 105.0

0.456

Proteinuria (g/d)cef

1.5(0.9–2.5)

1.8(0.7–2.9)

1.2(0.9–2.6)

0.8(0.4–1.3)

p < 0.001

nephrotic range proteinuria%cef

16.5

17.8

17.5

1.4

0.007

Hb(g/dL)

125.9 ± 22.1

129.0 ± 21.5

132.8 ± 20.8

132.0 ± 20.5

0.157

Alb (g/L)cef

36.8 ± 6.9

37.7 ± 5.8

38.2 ± 7.8

42.9 ± 5.2

p < 0.001

  1. aP < 0.05 between CTX and LEF group, bP < 0.05 between CTX and P group, cP < 0.05 between CTX and ACEI/ARB group,
  2. dP < 0.05 between LEF and P group, eP < 0.05 between LEF and ACEI/ARB group,
  3. fP < 0.05 between P and ACEI/ARB group
  4. MAP, mean arterial pressure; eGFR, estimated glomerular filtration rate; Cr, creatinine; UA, uric acid; Hb, hemoglobin; Alb, albumin.