Table 1 Components described on CA by immunohistochemical studies.

From: Exploring the elusive composition of corpora amylacea of human brain

Antibody

Epitope

CA staining

Ref.

Directed against Tau protein

Tau-2

phosphatase-independent epitope of tau

+

22

Tau 1, clone PC1C6

non-phosphorylated epitope of tau

22

PHF-1

Tau phosphorylated on ser396 and ser404

+

21

TauC3

caspase cleaved tau truncated at asp421

+

21

AT8

tau phosphorylated on ser202 and thr205

21

HT7

full-lenght tau

21

Tau46

tau C-terminal specific

+

21

AT8

tau phosphorylated at ser202 and thr205

23

Tau-2

human tau

+

23

PHF, clone AT100

tau phosphorylated on thr212 and ser214

24

Tau pS422

tau phosphorylated on ser422

24

Tau-5

tau 210–241 aminoacids

18

5E2

tau

18

Directed against Amyloid-β (Aβ) or amyloid-β protein precursor (APP)

4G8

Aβ 17-24 aminoacids

25

anti-Aβ 1-42

human Aβ 1-42

23

anti-Aβ

Aβ 1-40/42

+

24

P2

extracytoplasmic APP site

+

48

APP-A4, clone 22C11

N-terminal domain of APP

+

24

anti-Aβ1–42, 12F4

Aβ 1-42 aminoacids

18

anti-Aβ1–16, 6E10

Aβ 1-16 aminoacids

18

Directed against nestin

anti-nestin

nestin

25

anti-nestin

nestin

+

26

Directed against NeuN

anti-NeuN

NeuN protein

+(some)

25

anti-NeuN

NeuN protein

+

26

anti-NeuN

NeuN protein

+

27

Directed against synuclein (syn)

α/β/γ-syn, FL-140

human synuclein

+

23

anti-α-syn

α-synuclein protein

+

24

anti-α-syn

α-synuclein protein

+(some)

26

Directed against parkin

anti-parkin

human parkin

+

23

Directed against reelin

G10

reelin N-terminus

+

24

clone 142

reelin N-terminus

+

24

R12/14

reelin C-terminus

+

24

Directed against microtubule-associated protein 2 (MAP2)

anti-MAP2

MAP2

+

24

anti-MAP2

MAP2

+

30

Directed against neurofilaments

2F11

Neurofilament protein

+(some)

25

anti-NF70

Neurofilament protein

−(one+)

26

Directed against S100

S100 antisera

S100 proteins (different types, not S100B)

+

28

S100B antisera

S100B protein

28

anti-S100

glial S100 protein

+

26

anti-S100

glial S100 protein

+

25

anti-S100

glial S100 protein

+

29

Directed against glial fibrillary acidic protein (GFAP)

anti- GFAP

GFAP

+(some)

26

anti-GFAP

GFAP

+

25

anti-GFAP

GFAP

outlining

24

anti-GFAP

GFAP

outlining

31

anti-GFAP

GFAP

outlining

30

anti-GFAP

GFAP

outlining

29

Directed against ubiquitin

anti-ubiquitin

ubiquitin

+

21

anti-ubiquitin

ubiquitin

+

25

anti-ubiquitin

human ubiquitin

+

31

anti-ubiquitin

human ubiquitin

+

23

anti-ubiquitin

ubiquitin

+

2

Directed against heat-shock proteins (HSP)

anti-HSP70

HSP70

+

26

anti-HSP27

HSP27

−(some outlining)

49

anti-HSP70-72

HSP70-72

−(some outlining)

49

anti-HSP90

HSP90

−(some outlining)

49

anti-HSP28

HSP28

+

2

anti-HSP70

HSP70

+

2

anti-HSP72

HSP72

outlining/+

32

anti-HSP60

HSP60 383-447

+

33

Directed against aquaporin 4 (AQP4)

anti-aquaporin 4

AQP4

+

25

anti-aquaporin 4

AQP4

outlining

31

Directed against advanced glycation end-products (AGE)

6D12

CML (N-(carboxymethyl)lysine)

+

42

anti-pentosidine

pentosidine

+

42

Directed against proteoglycans

anti-proteoglycan

keratan sulfate proteoglycan

+

50

anti-glycoconjugage

mannose rich glycoconjugate

+

50

Directed against mitochondrial (mit.) epitopes

anti-Bcl-2

mit. membrane associated protein Bcl-2

+

51

Directed against transcriptional factors

anti-c-Jun/AP1

activator prot. 1 transcriptional factor c-Jun

+

51

Directed against transglutaminases (TGs) or products generated by TG

anti-TG2

guinea pig TG2

23

anti-TG1

human TG1

+

23

81D4

H-Glu(H-Lys-OH)-OH

+

23

Directed against cytoskeletal proteins

anti-β-tubulin III

β-tubulin III

+

23

anti-β-actin

β-actin

+

23

Directed against thrombospondin

A6.1

thrombospondin1

+

14

SPM321

thrombospondin1

+

14

Directed against ADAMTS3

anti-ADAMTS13

ADAMTS13

+

14

Directed against hypoxia-inducible factor 1-alpha (HIF-1α)

anti-HIF-1α

HIF-1α

+

25

Directed against endothelin B receptor

anti-ETBR

endothelin B receptor

+

52

Directed against fungal proteins

antifungal antibodies

C. glabrata, C. famata, C. albicans, …

+(neurodeg.)

17

Directed against herpesvirus

anti-cytomegalovirus

tegument protein pp65

+

16