Figure 1
From: DNA hypermethylation and differential gene expression associated with Klinefelter syndrome
DNA methylation between KS and controls. (A) Principal component analysis plot of the 5000 most variable autosomal CpG positions between KS (green), male controls (blue) and female controls (orange). (B) Principal component analysis plot of the 100 most variable X chromosomal CpG positions between KS (green) and female controls (orange). (C) Venn diagram of autosomal differentially methylated positions with FWER < 0.05 and absolute delta-M-value > 1. (D) Volcano plots of −log 10 (Familiy Wise Error rate = Bonferroni) against delta-M values of differentially methylated positions adjusted for age and relative cell proportion. Orange dots are differentially methylated positions with FWER < 0.05 and absolute delta-M-value > 1. Red line represents FWER = 0.05. The first three panels represents autosomal DMPs. (E) Manhattan plot of autosomal differentially methylated positions between KS and male controls. Blue dots are differentially methylated positions with FWER < 0.05 and absolute delta-M-value > 1. Red line represents FWER = 0.05. (F) Manhattan plot of autosomal differentially methylated positions between KS and female controls. Blue dots are differentially methylated positions with FWER < 0.05 and absolute delta-M-value > 1. Red line represents FWER = 0.05.
