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Figure 2

From: Nystatin-like Pseudonocardia polyene B1, a novel disaccharide-containing antifungal heptaene antibiotic

Figure 2

Development of nystatin-like Pseudonocardia polyene (NPP) B1 overproducing strains in Pseudonocardia autotrophica. (A) Inactivation scheme of enoyl reductase (ER) domain in module 5 (ER5) of nppC gene; KS, ketosynthase; AT, acyltransferase; DH, dehydratase; ER, enoyl reductase; KR, ketoreductase; ACP, acyl carrier protein. (B) Deletion scheme of P. autotrophica originated plasmid. (C) Comparison of NPP B1 production yields with newly constructed NPP B1 overproducing strains.

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