Table 1 In vitro antifungal activity and toxicity of polyene macrolides.

From: Nystatin-like Pseudonocardia polyene B1, a novel disaccharide-containing antifungal heptaene antibiotic

 

Nystatin A1

NPP A1

Amphotericin B

NPP B1

Antifungal activity (MIC, µg/mL)a

Candida albicans KCTC7965

4

16

1

2

C. albicans SC5314

4

16

1

4

C. albicans SL28

4

16

1

4

C. albicans SL38

4

16

1

2

Cryptococcus humicola ATCC9949

—

—

0.5

1

Saccharomyces cerevisiae ATCC9035

—

—

1

2

Hemolytic activity (MHC, µg/mL)b

 

66.17 ± 0.90

459.35 ± 32.5

4.65 ± 0.17

13.60 ± 0.19

  1. aMIC, minimum inhibitory concentration (values resulting in no visible growth of C. albicans).
  2. bMHC, minimum hemolytic concentration (values causing 90% hemolysis against horse blood cells ± percentage standard deviation).
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