Figure 3 | Scientific Reports

Figure 3

From: Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

Figure 3

Activity of lesinurad in a full-length PPARγ reporter gene assay compared to reference agonists rosiglitazone and pioglitazone: With an EC50 value of 21 ± 2 µM, lesinurad was equally potent on full-length PPARγ as on the hybrid receptor and revealed higher transactivation efficacy than pioglitazone and rosiglitazone. Results are mean ± SEM of at least three independent experiments; *p < 0.05, **p < 0.01, ***p < 0.001.

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