Figure 2 | Scientific Reports

Figure 2

From: BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts

Figure 2

Predicted risks by genetic risk scores. (A) Relative risks by genetic risk scores (GRSs) across the population. For two different types of markers sets (“BRCAX-known”: markers replicated for Korean BRCAX cases among previously reported breast cancer-associated markers from the GWAS catalog; “BRCAX-known + novel”: three novel candidate markers added to replicated markers), a predictive performance by GRSs was estimated for Korean BRCAX, Asian, and European high-risk cases. For BRCAX-known markers, predictive performance by GRSs was highest for Korean BRCAX followed by European and Asian high-risk cases. When three novel markers were added, however, prediction improved for Asians compared to Europeans. (B) Predicted risks of breast cancer according to three risk groups using the number of risk alleles of three consistently reported markers from three previous GWAS of BRCAX across the population: FGFR2 (rs2912774), TOX3 (rs4784227), and ESR1 (rs9383936). (C) Predicted BRCAX risks by GRSs using BRCAX-known markers by tertile groups of three global BRCAX-associated markers (on FGFR2, TOX3, and near ESR1): circle symbols are for low-risk group (T1), triangle symbols are for moderate risk group (T2), and square symbols are for high-risk group (T3).

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