Table 1 Malignancy rates for thyroid nodules that did not meet adequacy criteria and subsequent resection according to sonographic patterns and six nondiagnostic or unsatisfactory subcategories modified from the Bethesda System for Reporting Thyroid Cytopathology from April 2011 to March 2016.

From: Modified Bethesda system informing cytopathologic adequacy improves malignancy risk stratification in nodules considered benign or atypia(follicular lesion) of undetermined significance

FNA cytopathology

ATA nodule sonographic patterns

All FNAs (Number)

Surgically resected nodules (Number)

Malignant nodules confirmed by surgery (Number)

Malignancy rate

% maximum*

% minimum

Nondiagnostic

High suspicion

30

9

8

88.9%

26.7%

Others

201

10

4

40.0%

2.0%

Overall

231

19

12

63.2%

5.2%

Unsatisfactory + Benign

High suspicion

76

10

7

70.0%

9.2%

Others

836

50

15

30.0%

1.8%

Overall

912

60

22

36.7%

2.4%

Unsatisfactory + AUS/FLUS

High suspicion

79

35

32

91.4%

40.5%

Others

132

34

18

52.9%

13.6%

Overall

211

69

50

72.5%

23.7%

Unsatisfactory + FN/SFN

High suspicion

0

0

0

NA

NA

Others

3

2

0

0.0%

0.0%

Overall

3

2

0

0.0%

0.0%

Unsatisfactory + Suspicious for malignancy

High suspicion

54

41

41

100.0%

75.9%

Others

21

13

12

92.3%

57.1%

Overall

75

54

53

98.1%

70.7%

Unsatisfactory + Malignant

High suspicion

17

8

8

100.0%

47.1%

Others

1

1

1

100.0%

100.0%

Overall

18

9

9

100.0%

50.0%

Total

High suspicion

256

103

96

93.2%

37.5%

Others

1194

110

50

45.5%

4.2%

Overall

1450

213

146

68.5%

10.1%

  1. Abbreviations: FNA: fine-needle aspiration; ATA: American Thyroid Association; AUS/FLUS: atypia (or follicular lesion) of undetermined significance; FN/SFN: follicular neoplasm or suspicious for a follicular neoplasm; NA: not applicable.
  2. *Percentage of cases calculated from total number of resected cases in each category (maximum malignancy rate).
  3. Percentage of cases calculated from total number of fine-needle aspirations in each category (minimum malignancy rate).