Table 2 Significant polymorphism × sodium interaction influencing SBP.

From: Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus

SNP

Chr

Position*

Rsq†

CG

OG

Population

CGF

βGE

SE (βGE)

P ‡

rs8022678

14

99,366,690

0.991

GG

AG/AA

Discovery

0.520

−0.064

0.013

4.7 × 10−6

      

Replication

0.549

−0.049

0.014

4.1 × 10−4

      

Combined

0.534

−0.056

0.010

4.3 × 10−9

  1. *Chromosomal position was according to GRCh37/hg19 assembly.
  2. †Imputation quality in terms of R-square was estimated by Minimac3 software version 1.0.11.
  3. ‡P-value for the discovery cohort was corrected by genomic control method.
  4. SBP, systolic blood pressure; Chr, chromosome; CG, coded genotype; OG, other genotype; CGF, coded genotype frequency; βGE, effect size of interaction term; SE, standard error.
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