Table 4 Sodium effect on blood pressure stratified by rs8022678 genotype in the replication cohort.
rs8022678 | Variable | Tertile of daily sodium consumption | ||
|---|---|---|---|---|
T1 (Low) | T2 (Medium) | T3 (High) | ||
All | Range, mEq/day (mg/day) | <159.9 (<3,678) | 159.9–191.7 (3,678–4,409) | >191.7 (>4,409) |
SBP (mean ± SD), mm Hg | 128.9 ± 17.7 | 131.6 ± 17.6 | 133.9 ± 17.6 | |
Mean difference in SBP, mm Hg | ref. | 2.7 | 5.0 | |
P | ref. | 7.8 × 10−5 | 3.6 × 10−13 | |
DBP (mean ± SD), mm Hg | 75.2 ± 10.3 | 76.4 ± 10.2 | 77.5 ± 10.4 | |
Mean difference in DBP, mm Hg | ref. | 1.2 | 2.3 | |
P | ref. | 2.9 × 10−3 | 1.6 × 10−8 | |
GG homo | SBP (mean ± SD), mm Hg | 129.7 ± 17.7 | 131.7 ± 17.1 | 133.2 ± 17.3 |
Mean difference in SBP, mm Hg | ref. | 2.0 | 3.5 | |
P | ref. | 1.1 × 10−2 | 4.9 × 10−5 | |
DBP (mean ± SD), mm Hg | 75.5 ± 10.4 | 76.1 ± 10.1 | 77.3 ± 10.4 | |
Mean difference in DBP, mm Hg | ref. | 0.7 | 1.8 | |
P | ref. | 2.1 × 10−1 | 7.1 × 10−4 | |
A carrier | SBP (mean ± SD), mm Hg | 128.0 ± 17.6 | 131.5 ± 18.1 | 134.9 ± 18.1 |
Mean difference in SBP, mm Hg | ref. | 3.5 | 6.9 | |
P | ref. | 2.1 × 10−3 | 2.6 × 10−10 | |
DBP (mean ± SD), mm Hg | 74.9 ± 10.3 | 76.7 ± 10.2 | 77.7 ± 10.4 | |
Mean difference in DBP, mm Hg | ref. | 1.8 | 2.8 | |
P | ref. | 2.3 × 10−3 | 2.7 × 10−6 | |
