Figure 3 | Scientific Reports

Figure 3

From: Enhanced uptake of gH625 by blood brain barrier compared to liver in vivo: characterization of the mechanism by an in vitro model and implications for delivery

Figure 3

Fluorescence microscopy analysis of brain and liver slices of NBD-gH625 treatment. Experimental classes are expressed in μg per 100 gr of body weight. Scale bar 50 μm. (a) Integrated density of brain slices from rats injected with different concentration of NBD-gH625. **P < 0.01, ***P < 0.001. (b) Integrated density of liver slices from rats injected with different concentrations of NBD-gH625. **P < 0.01, ***P < 0.001. (c) Calibration curve representing the linear relationship between the known amounts of NBD-gH625 and the relative the integrated density obtained under the setup of the microscopy analysis system used. (d) Percentage of NBD-gH625 delivered in brain and liver after in vivo administration of NBD-gH625.

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