Figure 4 | Scientific Reports

Figure 4

From: Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus

Figure 4

NOD/ShiLtJ male iPSC were transcriptionally distinct. (A) Global gene expression PCA plot of cell treatment and sex for all samples. Cells clustered according to cell state and treatment. ESC clustered together at the bottom left. EpiSC clustered together at the top left. iPSC clustered in the center of the graph and separated according to individual iPSC treatment. Male NOD/ShiLtJ iPSC grown in 2iS clustered apart from all other iPSC, ESC, and EpiSC colonies. (B) The transcriptional profiles of male and female iPSC from NOD/ShiLtJ, WSB/EiJ, and 129S1/SvImJ were compared. NOD/ShiLtJ male iPSC differed transcriptionally from other male and female iPSC. NOD/ShiLtJ male iPSC have a lower expression of most genes than male and female 129S1/SvImJ and WSB/EiJ strains.

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