Figure 2 | Scientific Reports

Figure 2

From: Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer

Figure 2

Effects of NCT-50 on the viability and colony formation of NSCLC cells. (a) NSCLC (H1299, H460, A549 and H226B) cells and those carrying resistance to cisplatin (H1299/CsR), pemetrexed (H1299/PmR), and paclitaxel (H226B/PcR) were treated with increasing concentrations of NCT-50 (a) for 3 days. Cell viability was determined by the MTT assay. (b,c) The anchorage-dependent (b) and -independent (c) colony formation of NSCLC cells treated with increasing concentrations of NCT-50 was determined as described in Methods. (d) H460 cells were treated with increasing concentrations of ganetespib (Gane) or PU-H71 (PU) for 3 days. Cell viability was determined by the MTT assay. The bars represent the mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 by Student’s t-test compared with vehicle-treated control group.

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