Table 1 Qiagen Ingenuity Pathway Analysis identifies several pathways to be enriched, when comparing those hits detected in BH4 replete, verses deplete endothelial cells.

From: Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

Canonical Pathways

−log (p-value)

Ratio

Protein Ubiquitination Pathway

11.1

0.11

EIF2 Signaling

11

0.118

Signaling by Rho Family GTPases

9.91

0.105

RhoGDI Signaling

7.7

0.11

Cardiac Hypertrophy Signaling

3.93

0.0681

Chemokine Signaling

3.66

0.113

Endothelin-1 Signaling

3.39

0.0695

Mitochondrial Dysfunction

3.21

0.0702

Hypoxia Signaling in the Cardiovascular System

3.14

0.108

Tight Junction Signaling

2.76

0.0659

TCA Cycle II (Eukaryotic)

2.76

0.174

Wnt/β-catenin Signaling

2.72

0.0651

Glutathione Redox Reactions II

2.51

0.5

Proline Biosynthesis I

2.51

0.5

NF-κB Signaling

2.51

0.0611

Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate

2.3

0.4

NRF2-mediated Oxidative Stress Response

2.28

0.057

VEGF Signaling

2.01

0.068

eNOS Signaling

2.01

0.0581

Oxidative Phosphorylation

1.88

0.0642

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