Figure 4

(a) In the TCGA cohort the distribution of TCGA RNA-expression subtypes significantly differs according to CDKN2A copy number status (Chi² 0.016). (b) Vice versa there were significant differences in the CDKN2A expression in these subtypes (bas squam = basal squamous, lum = luminal, lum inf = luminal infiltrated, lum pap = luminal papillary, neur = neuronal). Of the analyzed, typically subtype defining, genes, KRT20, GATA3 and FOXA1 showed a differing expression in the CDKN2A expression groups (c–e). (*p < 0.05; **p < 0.01; ***p < 0.001).