Figure 4
Behavioral measurements. Pain: noxious stimulus. The Paw pressure test was used to measure the sensitivity to a mechanical stimulus. Animals were treated daily i.p. with 2.4 mg kg−1 of oxaliplatin. Vitis vinifera extract (300 mg kg−1) was daily per os administered starting from the first day of oxaliplatin injection and behavioral evaluations were performed after 14 and 21 days of treatment, 60 min and 24 h after Vitis vinifera administration. Control animals were treated with vehicles. Each value represents the mean ± s.e.m. of 10 rats per group, performed in 2 different experimental sets carried out by experimenters blinded to the treatments. **P < 0.01 vs vehicle + vehicle; ^^P < 0.01 vs oxaliplatin + vehicle.
