Figure 6 | Scientific Reports

Figure 6

From: Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity

Figure 6

Gene expression analysis identifies distinct gene signature enrichment in PF-429242 treated plasmablasts. (A) Day 3 B-cells from 6 donors were treated with 10 μM PF-429242 or vehicle control (dH2O) and analyzed on day 6 using Illumina bead arrays. (B) Selected genes showing greater than 1.4-fold change in expression are depicted. (C) Enrichment of gene signatures was determined using a hypergeometric test against a curated set of 28,000+ signatures and ontology term associations. Enriched signatures and ontologies were clustered according to genes contributing to enrichment with summary labels shown on the right.

Back to article page