Figure 1
Ex vivo differential mycobacterial control is associated with disease state in pre-treatment whole blood. Samples were collected from volunteers before starting anti-TB treatment. Whole blood MGIT using BCG Pasteur (A) and M.tb H37Rv (B) was performed and data meeting the inclusion criteria (duplicate ΔTTP < 6 hours) are shown (BCG: n = 11, n = 93, n = 35; H37Rv: n = 19, n = 101, n = 51; for active TB, LTBI and healthy controls, respectively). The association between BCG and H37Rv pre-treatment MGIT results was evaluated by Pearson’s correlation (C). Points represent the mean of duplicates; bars represent mean values with SD. A one-way multiple comparison ANOVA with Tukey’s post-test correction was performed between the groups. *Represents a p-value of <0.05, **a p-value of <0.005, ***a p-value of <0.0005 and ****a p-value of <0.0001.
