Figure 6 | Scientific Reports

Figure 6

From: A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein

Figure 6

Nestin expression is lower in atherosclerotic plaque vs. normal artery. mRNA was prepared from 127 human carotid atherosclerotic plaques and 10 normal arteries and analysed by microarray to determine: (A) total NES mRNA expression and (B) the ratio of NES mRNA relative to the EC markers VWF or CD34. Unpaired t-test ****p-value < 0.0001. Sections of (C,D) normal artery or (E,F) carotid plaque were stained by immunohistochemistry for (C,E) NES or (D,F) both NES and VWF protein expression. Arrows highlight blood vessel EC.

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