Figure 7
From: The Role of p53 in Determining Mitochondrial Adaptations to Endurance Training in Skeletal Muscle
Adaptive mitochondrial responses with training in two mouse models. Following the 6-week training/sedentary protocol, the WT and muscle-specific (mKO) and whole-body (WB) p53 knockout mice were subjected to an exhaustive exercise test. (A) Distance to exhaustion in both mouse models (n = 6–9/group); **p ≤ 0.01, UT vs. T, 2-way ANOVA. (B) COX activity (n = 6–8/group); **p ≤ 0.01, UT vs. T, Student’s t-test and 2-way ANOVA; †p ≤ 0.05, UT WT vs. KO, Student’s t-test. C) PGC-1α protein (n = 5–10/group); *p ≤ 0.05, **p ≤ 0.01, UT vs. T, Student’s t-test and 2-way ANOVA; †p ≤ 0.05, ††p ≤ 0.01, UT WT vs. KO, Student’s t-test. Some of the data presented in Fig. 2 are replicated here in Fig. 7 for comparison. Data are presented as mean ± SEM.
