Figure 2
From: A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus
Clinical outcome in animals given retrorsine. (a–c) H & E staining of liver from (a) a pig receiving 30 mg/kg RS, dying 3 days after the first RS injection, (b) a pig receiving 50 mg/kg RS, dying 26 days after the second RS injection and (c) a pig receiving 100 mg/kg RS, dying on the day after the second injection of RS. (d) Kaplan-Meier survival curves for follow-up of 21 pigs after the first injection of RS. (e,f) Clinical scores of appetite (e) and activity (f) of pigs after 0 or 50 mg/kg RS treatment (mean + SD). *P < 0.05.
