Figure 3
From: A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus
Retrorsine concentration in liver tissue and blood and liver regeneration in animals after hepatectomy with/without retrorsine. (a) RS concentration in liver tissue of animals which received 30 and 50 mg/kg RS and control animals at the time of PH and 10 day post-PH (mean + SD). There was no significant difference among the groups. (b) RS concentration in blood of animals which received 50 mg/kg RS at the time of 7 days after second injection of RS. The significance of difference was not able to be evaluated due to the small number of samples. (c) RS concentration in blood and liver tissues from a pig exposed to 100 mg/kg RS. (d) PLR of in pigs exposed to 0 mg/kg or 50 mg/kg RS whose liver contained 0.0477 ng/g RS on day 10 after PH (mean + SD). ***P < 0.001. (e) BW-PLR in pigs exposed to 0 mg/kg or 50 mg/kg RS (mean + SD). *P < 0.05. (f) Body weight of pigs exposed to 0 mg or 50 mg RS (mean + SD).
