Table 1 Clinical characteristics at baseline.

From: Quantitative B-lymphocyte deficiency and increased TCRγδ T-lymphocytes in acute infectious spondylodiscitis

 

Baseline n = 35

Female gender, n (%)

9 (26)

Age, median years (IQR)

61 (48–66)

Days from onset of symptoms to (median (IQR)

Appropriate intravenous antimicrobials

22 (6–71)

Diagnosis

26 (14–70)

Inclusion in study

52 (32–111)

Immunosuppressivea treatment <4 weeks prior to admission, n (%)

6 (17)

Days from last dose of prednisolone to inclusion in study, median (IQR)

16 (8–22)

Aetiology, n (%)

Monomicrobial

23 (66)

Staphylococcus aureus

9 (40)

Streptococcus species

3 (13)

Escherichia coli

2(6)

Mycobacteriaeb

4 (11)

Otherc

6 (26)

Polymicrobial

3 (9)

Staphylococcus aureus

1 (33)

Streptococcus species

2 (67)

Escherichia coli

1 (33)

Otherc

2 (67)

No confirmed aetiology

9 (26)

Site of infection, n (%)

Cervical

2 (6)

Thoracic

11(31)

Lumbosacral

18 (51)

Multiple foci

4 (11)

Other foci, n (%)

Abscess formation

24 (69)

Otherd

3 (9)

Comorbidities, n (%)

Single comorbidity

10 (29)

Multiple comorbidities

12 (34)

Diabetes Mellitus type 2

3 (9)

Bone or joint disease

5 (14)

Alcohol abuse

6 (17)

Previous back surgery

4 (11)

Active IV abuse

2 (6)

Othere

25 (71)

Biochemistry at admission

Sedimentation rate, mm/h, median (IQR)

76 (54–99)

Elevated (>15 mm/h), n (%)

26/27 (96)

Haemoglobin, mmol/l, median (IQR)

7.3 (6.5–7.8)

Low (<7.3 for females, <8.3 for males), n (%)

25/34 (74)

C-reactive protein, mg/l, median (IQR)

62 (23–124)

Elevated (>10 mg/l), n (%)

31/33 (94)

White blood cell (WBC) count, *109/l, median (IQR)

8.5 (6.8–10.8)

Elevated (>8.8), n (%)

16/35 (46)

Low (<3.5), n (%)

1/35 (3)

Neutrophils, *109/l, median (IQR)

6.0 (4.4–7.3)

Elevated (>7.4), n (%)

6/35 (17)

Low (<1.8), n (%)

2/35 (6)

Monocytes, *109/l, median (IQR)

0.5 (0.4–0.8)

Elevated (>1.1), n (%)

3/31 (10)

Lymphocytes, 109/l, median (IQR)

1.7 (1.18–2.21)

Low (<0.7), n (%)

4/33 (12)

Thrombocytes, 109/l, median (IQR)

289 (231–387)

Elevated (>390), n (%)

8/33 (24)

Low (<145), n (%)

1/33 (3)

  1. For elevated/low levels of a given parameter, counts equal to zero (0%) are not shown. aAll patients on immunosuppressive treatment prior to inclusion were treated with prednisolone. bThree cases with Mycobacterium tuberculosis, one case with atypical mycobacteria. cHaemophilus influenzae, Salmonella enterica, Enterococcus faecalis, Haemophilus aprophilius, streptococcus anginosus, citrobakter freundii, Enterobacter cloaca, Klebsiella pneumoniae. dMeningitis, Sepsis, Septic Arthritis. eCardiovascular disease, chronic lung condition, chronic liver condition, chronic kidney failure, rheumatic diseases, previous malignancies.
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