Figure 3

Hyperpolarised ¹³C imaging in the porcine brain. (A–C) Example summed [1-¹³C]pyruvate, summed [1-¹³C]lactate and k_P maps of the porcine brain post saline infusion, respectively. Here no detectable lactate signal is observed post bolus, with [1-¹³C]pyruvate appearing in the major vessels of the brain. (D–F) Representative [1-¹³C]pyruvate, [1-¹³C]lactate, and k_P of the porcine brain post mannitol infusion, respectively. Here lactate exchange is observed globally, post infusion, with a similar distribution of [1-¹³C]pyruvate signal in the major vessels as seen in (A). The object seen in the posterior of the pig is the [1-¹³C bicarbonate] sphere used for transmit gain and centre frequency calibration.