Figure 4
From: 13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI
Kinetic analysis of the porcine brain. (A) Average [1-13C]pyruvate and [1-13C]lactate time course data from regions of interest placed in porcine brains reveals inflow and decay of the [1-13C]pyruvate signal post saline and mannitol. Lactate exchange is observed post mannitol infusion. Lactate normalised to peak [1-13C]pyruvate signal in both cases, displayed (x3) for ease of viewing. (B) Average [1-13C]lactate to [1-13C]pyruvate ratio for all porcine experiments An increase in the exchange of [1-13C]lactate from the increased permeability of the blood-brain barrier is observed (*p < 0.05, effect size = 31, mean ± SD). (C) Increase in kP after disruption of the blood- brain barrier (*p < 0.05, effect size = 4.5, mean ± SD).
