Figure 3

Platelet response to thrombin in platelets from HIV-infected individuals under stable cART and healthy volunteers. (A,B) The percentage of platelets with P-selectin surface expression (A) and the mean fluorescence intensity (MFI) for P-selectin labeling (B) on platelets from healthy subjects (control) or from HIV-infected individuals under viral control (HIV-1 viral load < 50 copies/ml in the peripheral blood) after stimulation with thrombin (0.05 U/mL, 0.1 U/mL, 0.2 U/mL and 0.4 U/mL). (C,D) The concentration of RANTES (C) or thromboxane B₂ (D) in the supernatant of platelets from control or HIV-1-infected subjects stimulated with each concentration of thrombin. The dots indicate the mean ± standard error of the mean of 5–10 HIV-infected individuals or healthy volunteers. Representative histograms are shown. The asterisk (*) signifies p < 0.05 between platelets from control or healthy volunteers stimulated with the same concentration of thrombin.