Figure 4 | Scientific Reports

Figure 4

From: MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes

Figure 4

PGC1-α mRNA is a target of miR-494-3p. (A) Predicted miR-494-3p target site in the 3′-untranslated region (UTR) of mouse PGC1-α and alignment with sequences in other species. The seed region is enclosed with a square box. (B) Luciferase reporter assays. Luciferase reporters containing the PGC1α wild-type or mutant 3′-UTR were transfected along with miR-494-3p precursor or scrambled sequence control into beige adipocytes for 48 h (n = 8). ***p < 0.001.

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