Figure 7
A proposed model for the roles of miR-494-3p in mitochondrial biogenesis and thermogenesis in beige adipocytes. In this model, cold/β3-AR adrenergic stimulation causes a decrease in miR-494-3p expression in beige adipocytes, thereby inducing mitochondrial biogenesis and thermogenesis. Catecholamine binds to β3-AR to activate the cAMP pathway and inhibit miR-494-3p expression, reducing the inhibitory activity of miR-494-3p on PGC1-α gene expression. β3-AR: β3- adrenergic receptor; AC: adenylate cyclase; cAMP: cyclic AMP; PKA: protein kinase A; HSL: hormone sensitive lipase; TFAM: mitochondrial transcription factor A; mtDNA: mitochondrial DNA; UCP1: uncoupling protein 1.
