Figure 2 | Scientific Reports

Figure 2

From: Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules

Figure 2

Total HIV DNA levels in CD4 T cells in ECs and LTNPs compared to NCARTs. (a,b) Total HIV DNA was measured in CD4+ T cells. NCART 004, NCART 008, and LTNP 009 were not measured for total HIV DNA due to primer-probe mismatch. (a) Median for each group are shown, p-values are calculated using Mann Whitney test. (b) DNA levels for the individual patients: Error bars represent min and max values from technical replicates. (c,d) Total HIV DNA copies per million CD4+ T cells are correlated to years with HIV infection in the EC and LTNP group (c) and the control group with NCARTs (d). The two-tailed p value from a Pearson correlation was 0.0526 for the ECs/LTNPs with R squared at 0.4368; and 0.1531 for the NCARTs with R squared at 0.2683. LTNP 011 was excluded from the analysis due to recent progression. Non-controller on ART (NCART); elite controller (EC); long-term non-progressor (LTNP).

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