Figure 4 | Scientific Reports

Figure 4

From: Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules

Figure 4

STRING association network for proteins affected by genetic variants within the HIV EC and LTNP patient cohort. Protein-protein interaction network for proteins encoded by genes with variants in the EC and LTNP cohort. PIK3R6 is not a part of the network due to absence from the database. Each circle represents a gene/protein affected by at least one variant in the cohort. Thickness of gray lines represents strength of data supporting association, i.e. proteins jointly contribute to a shared function. Interactions are made with STRING version 10.5 based on data from genomic context predictions, high-throughput experiments, co-expressions, automated text-mining, and database search. Circles are drawn around proteins involved in common pathways or with similar biological functions. The PPI enrichment p-value for the number of identified interactions (10) compared to expected (5) in a group of 19 proteins was 0.0492, thus significantly more than expected, with a minimum interaction score a 0.4.

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