Figure 3
From: Simultaneous targeting of linked loci in mouse embryos using base editing
Inheritance of intended mutations. (a) Female founder F883 was mated with a WT male and mutations in site C were analyzed in its offspring. F883 was homozygous for the intended C-to-T conversion on site C and all offspring were heterozygous for this mutation. The C-to-T editing is shown in green. (b) F165 was mated with male founder M183, and intended mutations and deletions are co-segregated. (c) The indel frequency and deletion length were analyzed in founder mice.
