Figure 5
Hierarchical clusters of activated or inhibited pathways in mice infected with four P. yoelii strains. Gene expression significantly (adjusted p-value < −0.05) changed by ANOVA between infected and uninfected mice were used as input to Parametric Analysis of Gene Set Enrichment (PAGE). (a) Clusters of Gene Ontology Biological Process terms with corresponding z-scores from PAGE in color scale. (b) Log2 fold change of individual genes in the gene set “Porphyrin synthesis” (as indicated by individual strain infected vs. uninfected; or by the ratio of one strain to another). Gene IDs: Fech, ferrochelatase (or heme synthetase); ank1, ankyrin; uros, uroporphyrinogen III synthase; urod, uroporphyrinogen decarboxylase; alad, aminolevulinate dehydratase; empb3, erythrocyte membrane protein band 3; alas2, aminolevulinate-delta dehydratase 2; hebp1, heme binding protein 1; blvrb, biliverdin reductase b; ppox, protoporphyrinogen oxidase; abcb6, ATP-binding cassette subfamily B member 6; Tmem14c, transmembrane protein 14C; cpox, coproporphyrinogen oxidase; fxn.
