Table 3 Two SNP haplotype analysis of intronic (rs4664308) and missense (rs35771982) (upper table) and three SNP haplotype analysis including the 5′ UTR SNP (rs3749119) (lower table). (222 IMN vs. 701 controls).

From: Identification of a two-SNP PLA2R1 Haplotype and HLA-DRB1 Alleles as Primary Risk Associations in Idiopathic Membranous Nephropathy

Risk Haplotype

Frequency (case/control)

OR (95% CI)

P

rs35771982-rs4664308 (2 SNPs)

GA

0.765/0.551

2.68 (2.1–3.42)

3.76 × 10−15

rs35771982-rs4664308-rs3749119 (3 SNPs)

GAC

0.767/0.559

2.7 (2.11–3.44)

1.15 × 10−14

  1. Two-SNP and three-SNP haplotypes are not different because 5′UTR SNP is the almost the same signal as the intronic SNP.
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