Figure 6 | Scientific Reports

Figure 6

From: Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells

Figure 6

Effects of BTK- and SHIP1-deficiency on Ag-triggered effector functions. WT, Btk−/− (or WT cells + Ibrutinib), Ship1−/−, and DKO MCs (or Ship1−/− cells + Ibrutinib) are opposed to each other in an exemplary manner. Extent of FcεRI crosslinking is specified as suboptimal (sub) or optimal (opt). The level of induction of the analysed effector functions, degranulation and cytokine production, is represented by letter size (deg < Deg < DEG; cyto < Cyto < CYTO).

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