Figure 6 | Scientific Reports

Figure 6

From: HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture

Figure 6

HPV16-immortalized cells from TZ and endocervix are more invasive. (a) HPV16-immortalized cells derived from ectocervix, TZ, or endocervix (all 85 population doublings) were grown for 10 days on rafts with either 3T3-J2 mouse cells or human stromal cells. Dotted lines indicate position of basement membranes. (b) Mean invasion index (degree of invasion into collagen raft) ± standard error of 24 different HPV16-immortalized cell lines (8 from ectocervix, TZ and endocervix) maintained in organotypic culture on rafts formed with 3T3-J2 cells or human stromal cells. Bars show values that are statistically different (3 asterisks = p < 0.001).

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