Figure 8 | Scientific Reports

Figure 8

From: HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture

Figure 8

Inhibition of Akt or MMP-1 blocks invasion of HPV16-immortalized cells. (a) HPV16-immortalized TZ cells were seeded on collagen rafts with cervical stromal cells and then treated for 10 days with the Akt inhibitor SC 66 (2 µg/ml) or the MMP inhibitor GM6001 (10 μM) in DMSO. Untreated cultures received only DMSO. Dotted lines indicate position of basement membranes. (b) Mean invasion index ± standard error of three organotypic cultures. Bars show values that are statistically different (3 asterisks = p < 0.001).

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